I am going to blame Bethesda's clunky old Creation engine on this one, but I just wanted to verify if anyone here has the same issue?
I disabled SLI just to rule that out as a problem.
When Gsync and Vsync are on I get stutters in random areas (usually outside) that are reproducible when walking through the same area again after the stutter stops.
When Gsync is on and Vsync is off, I get no stutters but the animals get physics wonked so I see a lot of hopping Wolfs, Deer, etc...
When I turn Gsync off, the game locks me to 60 fps eventhough my screen is set to 165 Hz in Nvidia control panel and for some reason, when panning around the world things just don't look as smooth as you'd expect from 60 fps.
 
So those are pretty much my choices, I tried going into the Skyrimpref file and turned Vsync on and off there manually but it has the same effect as just doing so from Nvidia control panel.
 
With Gsync on I usually get around 100 to 120 fps and everything looks great and smooth but the occasional stutters are just frequent enough to really be annoying.
 
System specs are in the sig.  If anyone plays the game as well and has found settings with as few compromises as possible, please let me know,
 
Thanks!

So you turn Gsync off and leave Vsync on and just deal with it that way?
 
Our systems are very similar, what temps are you getting on your CPU with the 4.3 overclock and at what voltage are you running?  My idle temps are usually in the upper 30s and during gaming upper 50s to low 60s.

I saw another guy having these issues and he locked in his framerates to either 99 or 89 max and it fixed it. 

I have severe stuttering, as well.  I disable G-Sync and just run the game locked to 60 FPS with 120 Hz ULMB instead.  This is the first game I've run that has issues with G-Sync.  Even Fallout 4 and Diablo III run with no issues for me.
 
Specs:
Gigabyte Z87X-UD3H
Intel Core i7-4770 w/ NZXT Kraken X31
Corsair Vengeance 32GB DDR3-1600
NVIDIA TITAN X (Pascal), 375.70 WHQL driver
ASUS ROG Swift PG278Q
Creative Sound Blaster Zx
Samsung 850 Pro 512GB (OS and game installed here)
Windows 10 Pro (1607 with all updates)

I do turn Vsync on along with Gsync enabled for games where my computer exceeds the 165 hz my Monitor can handle.  Case in point is Star Wars Battlefront which caps itself to 200 fps which is still too much for my screen. With Vsync off I get screen tearing when I exceed 165 fps which is why I turn it on.  Using Vsync for me is on a case by case basis, I just fiddle with it and use whatever gives me the best results.
 

Turn off GSYNC and use ULMB. There is definitely an issue with Skyrim SE edition while using GSYNC. Turn on ULMB under NVidia control panel, and then set VSYNC to adaptive. This will fix the issue.

I am thinking that I am going to be stuck with 60 fps because from what I read in forums specific to the game is that the physics engine goes wonky at anything over 60 fps.... pitty, really, game looks so much smoother at 100+ fps.

Skyrim's (original and new) physics rely upon 60FPS/60Hz.
 
Some folks have been successful running a little higher, but the game engine physics is coded around 60Hz.
 
If I were you I'd cap the game at 60FPS and play - either with VSYNC or GSYNC.

wils07
Turn vsync on in global settings along with gsync then disable vsync in game, this worked for me on a number of games.

Turning on Vsync in Nvidia control panel negates the game's vsync capabilities. Doesn't matter if you flip it on or off within game, you have forcefully activated it for all games (if it's on in global settings.)